Francesco Mancini was an Italian football goalkeeper and coach, best known for his association with Foggia during the 1990s. Mancini started his career at hometown club Matera in 1985. He later played for Bisceglie in 1987. Mancini joined Foggia in 1987 and remained with the club for a decade. He helped the club achieve Serie A promotion under manager Zdeněk Zeman, winning the 1990–91 Serie B title. He played 2 Serie B games for Foggia in the 1995–96 season, before leaving on loan for S.S. Lazio in November 1995. He returned to Foggia in the summer of 1996 and played another Serie B season with the club. In summer 1997, he joined A.S. Bari of Serie A, where he played 95 games in three Serie A seasons. In summer 2003, he joined Pisa of Serie C1 as Napoli choose to sign Manitta permanently. In January 2005, he transferred to Sambenedettese of Serie C1, in exchange for Domenico Di Dio. He then played for Teramo, Salernitana and A.C. Martina, all in Serie C1.